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Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation
http://hdl.handle.net/10131/0002001258
http://hdl.handle.net/10131/0002001258ac624d12-ff88-4394-8be5-c57344c78b15
| 名前 / ファイル | ライセンス | アクション |
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s41598-024-55377-y.pdf (1.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2024-09-25 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Cinnamic acid; Oxytocin receptor; Hair growth; Hair follicle organoid; Dermal papilla cells; Hair follicle | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
Kageyama, Tatsuto
× Kageyama, Tatsuto
ORCID
0000-0001-6248-3755
× Seo, Jieun
× Yan, Lei
× Fukuda, Junji
ORCID
0000-0002-7194-8099
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| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Considerable global demand exists for the development of novel drugs for the treatment of alopecia. A recent report demonstrated that oxytocin promotes hair growth activity in human dermal papilla (DP) cells; however, its application in drugs or cosmetic products is challenging because rapid degradation and relatively large molecular weight prevent long-term topical administration on the scalp. Here, we examined cinnamic acid, a small molecule activator for oxytocin receptor (OXTR) expression. Treatment with cinnamic acid led to upregulation of OXTR and trichogenic gene expression in human DP cells. Furthermore, inhibition of OXTR with an antagonist, L-371,257, suppressed hair growth-related gene expression in DP cells. These findings suggest that cinnamic acid enhances the hair growth ability of DP cells via oxytocin signaling. Additionally, we tested the hair growth-promoting effects of cinnamic acid using hair follicle organoids in vitro and observed that cinnamic acid significantly promoted the growth of hair peg-like sprouting. These promising results may be useful for developing hair growth-promoting products targeting oxytocin. | |||||||||||||
| 言語 | en | |||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 14, 号 1, ページ数 8, 発行日 2024-02-27 |
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| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-024-55377-y | |||||||||||||
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| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
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| 出版者 | Nature Portfolio | |||||||||||||
| 言語 | en | |||||||||||||
