{"created":"2024-09-25T05:14:36.082119+00:00","id":2001258,"links":{},"metadata":{"_buckets":{"deposit":"c3e99f7e-9e3a-4d79-889c-1d8a2128c223"},"_deposit":{"created_by":17,"id":"2001258","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2001258"},"status":"published"},"_oai":{"id":"oai:ynu.repo.nii.ac.jp:02001258","sets":["495:496"]},"author_link":[],"item_2_biblio_info_8":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicNumberOfPages":"8","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Considerable global demand exists for the development of novel drugs for the treatment of alopecia. A recent report demonstrated that oxytocin promotes hair growth activity in human dermal papilla (DP) cells; however, its application in drugs or cosmetic products is challenging because rapid degradation and relatively large molecular weight prevent long-term topical administration on the scalp. Here, we examined cinnamic acid, a small molecule activator for oxytocin receptor (OXTR) expression. Treatment with cinnamic acid led to upregulation of OXTR and trichogenic gene expression in human DP cells. Furthermore, inhibition of OXTR with an antagonist, L-371,257, suppressed hair growth-related gene expression in DP cells. These findings suggest that cinnamic acid enhances the hair growth ability of DP cells via oxytocin signaling. Additionally, we tested the hair growth-promoting effects of cinnamic acid using hair follicle organoids in vitro and observed that cinnamic acid significantly promoted the growth of hair peg-like sprouting. These promising results may be useful for developing hair growth-promoting products targeting oxytocin.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Portfolio","subitem_publisher_language":"en"}]},"item_2_relation_13":{"attribute_name":"item_2_relation_13","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-024-55377-y","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_9":{"attribute_name":"item_2_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_18":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kanagawa Academy Science & Technology","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Fac Engn, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Fac Engn, Inst Adv Sci, Yokohama National University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kageyama, Tatsuto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0001-6248-3755","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-6248-3755"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Fac Engn, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Fac Engn, Inst Adv Sci, Yokohama National University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Seo, Jieun","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kanagawa Academy Science & Technology","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Fac Engn, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Fac Engn, Inst Adv Sci, Yokohama National University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yan, Lei","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Kanagawa Academy Science & Technology","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Fac Engn, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Fac Engn, Inst Adv Sci, Yokohama National University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Fukuda, Junji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0002-7194-8099","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-7194-8099"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2024-02-27"}],"filename":"s41598-024-55377-y.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"s41598-024-55377-y.pdf","objectType":"fulltext","url":"https://ynu.repo.nii.ac.jp/record/2001258/files/s41598-024-55377-y.pdf"},"version_id":"5a477fec-41ec-403d-b845-56cfa6ea929f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cinnamic acid; Oxytocin receptor; Hair growth; Hair follicle organoid; Dermal papilla cells; Hair follicle","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["496"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-09-25"},"publish_date":"2024-09-25","publish_status":"0","recid":"2001258","relation_version_is_last":true,"title":["Cinnamic acid promotes elongation of hair peg-like sprouting in hair follicle organoids via oxytocin receptor activation"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-09-25T05:14:42.982308+00:00"}