WEKO3
アイテム
Electrical stimulation, Dermal papilla cell, Polypyrrole, Tissue engineering, Hair regenerative medicine
http://hdl.handle.net/10131/0002001195
http://hdl.handle.net/10131/00020011951485c529-08ff-403a-a62a-828710c06d85
| 名前 / ファイル | ライセンス | アクション |
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本文へのアクセスはこちら
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2024-09-02 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Electrical stimulation, Dermal papilla cell, Polypyrrole, Tissue engineering, Hair regenerative medicine | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | TeratogenicityPluripotent stem cellsFibroblast growth factorSignal disruptionSignal reporter assay | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | metadata only access | |||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||||||||||
| 著者 |
Yan, Lei
× Yan, Lei
ORCID
0000-0002-6091-8732
× Kageyama, Tatsuto
ORCID
0000-0001-6248-3755
× Zhang, Binbin
ORCID
0000-0002-2488-4221
× Yamashita, Seiya
ORCID
0000-0001-7313-5916
× Paul, J. Molino
ORCID
0000-0002-8868-2733
× Gordon, G. Wallace
× Fukuda, Junji
ORCID
0000-0002-7194-8099
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Hair follicle dermal papilla cells (DPCs) are specialized mesenchymal cells that play pivotal roles in hair formation, growth, and cycles, and they are considered as a cell source in hair regenerative medicine. Rodent dermal papilla cells have been shown to induce de novo hair follicle generation in the skin of recipients following transplantation, suggesting that dermal papilla cells can reprogram epidermal microenvironments. However, human DPCs (hDPCs) lose their ability to generate de novo hair follicles under conventional culture methods. We investigated the effects of electrical stimulation (ES) on hDPCs to restore the depressed trichogenic activity. We demonstrated that ES with a polypyrrole (PPy)-modified electrode upregulated trichogenic gene expression in hDPCs in vitro, and the activated cells when transplanted into mice generated double the number of hairs compared to that without the ES. Using specific inhibitors, we revealed that the mechanisms behind the electrical activation are associated with voltage-gated ion channels. Further, ES can be adapted for hDPCs from a patient with androgenic alopecia. Thus, this approach is potentially beneficial in preparing hDPCs for hair regenerative medicine. | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 書誌情報 |
en : Journal of Bioscience and Bioengineering 巻 133, 号 3, p. 281-290, ページ数 10, 発行日 2022-03 |
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 13891723 | |||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA11307678 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.jbiosc.2021.12.003 | |||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
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| 出版者 | Society for Biotechnology, Japan | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 出版者 | Elsevier | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
