{"created":"2024-09-03T01:10:13.495568+00:00","id":2001195,"links":{},"metadata":{"_buckets":{"deposit":"b64c3fff-7bc2-4dad-8382-5b3ced598f14"},"_deposit":{"created_by":17,"id":"2001195","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2001195"},"status":"published"},"_oai":{"id":"oai:ynu.repo.nii.ac.jp:02001195","sets":["495:496"]},"author_link":[],"item_2_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicNumberOfPages":"10","bibliographicPageEnd":"290","bibliographicPageStart":"281","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"Journal of Bioscience and Bioengineering","bibliographic_titleLang":"en"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hair follicle dermal papilla cells (DPCs) are specialized mesenchymal cells that play pivotal roles in hair formation, growth, and cycles, and they are considered as a cell source in hair regenerative medicine. Rodent dermal papilla cells have been shown to induce de novo hair follicle generation in the skin of recipients following transplantation, suggesting that dermal papilla cells can reprogram epidermal microenvironments. However, human DPCs (hDPCs) lose their ability to generate de novo hair follicles under conventional culture methods. We investigated the effects of electrical stimulation (ES) on hDPCs to restore the depressed trichogenic activity. We demonstrated that ES with a polypyrrole (PPy)-modified electrode upregulated trichogenic gene expression in hDPCs in vitro, and the activated cells when transplanted into mice generated double the number of hairs compared to that without the ES. Using specific inhibitors, we revealed that the mechanisms behind the electrical activation are associated with voltage-gated ion channels. Further, ES can be adapted for hDPCs from a patient with androgenic alopecia. Thus, this approach is potentially beneficial in preparing hDPCs for hair regenerative medicine.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Biotechnology, Japan","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_2_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jbiosc.2021.12.003","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11307678","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13891723","subitem_source_identifier_type":"PISSN"}]},"item_2_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Fac Engn, Hodogaya Ward, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Faculty of Engineering, Yokohama National University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yan, Lei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0002-6091-8732","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-6091-8732"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Engineering, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Kanagawa Institute of Industrial Science and Technology","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kageyama, Tatsuto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0001-6248-3755","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-6248-3755"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Engineering, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Kanagawa Institute of Industrial Science and Technology","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Zhang, Binbin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0002-2488-4221","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-2488-4221"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Engineering, Yokohama National University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yamashita, Seiya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0001-7313-5916","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-7313-5916"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Paul, J. Molino","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0002-8868-2733","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-8868-2733"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Gordon, G. Wallace","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Engineering, Yokohama National University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Kanagawa Institute of Industrial Science and Technology","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Fukuda, Junji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"0000-0002-7194-8099","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-7194-8099"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateValue":"2024-02-25"}],"fileDate":[{"fileDateType":"Issued","fileDateValue":"2022-02-24"}],"filename":"本文へのアクセスはこちら","licensetype":"license_note","url":{"label":"本文へのアクセスはこちら","objectType":"fulltext","url":"https://www.sciencedirect.com/science/article/am/pii/S1389172321003303"},"version_id":""}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TeratogenicityPluripotent stem cellsFibroblast growth factorSignal disruptionSignal reporter assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Electrical stimulation, Dermal papilla cell, Polypyrrole, Tissue engineering, Hair regenerative medicine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Electrical stimulation, Dermal papilla cell, Polypyrrole, Tissue engineering, Hair regenerative medicine","subitem_title_language":"en"}]},"item_type_id":"2","owner":"17","path":["496"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-09-02"},"publish_date":"2024-09-02","publish_status":"0","recid":"2001195","relation_version_is_last":true,"title":["Electrical stimulation, Dermal papilla cell, Polypyrrole, Tissue engineering, Hair regenerative medicine"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-09-03T01:10:17.500108+00:00"}