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In vitro hair follicle growth model for drug testing
http://hdl.handle.net/10131/0002001267
http://hdl.handle.net/10131/00020012677b39c011-969f-4434-9f93-8adcb0ed1f90
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
s41598-023-31842-y.pdf (2.2 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2024-09-25 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | In vitro hair follicle growth model for drug testing | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 著者 |
Kageyama, Tatsuto
× Kageyama, Tatsuto
ORCID
0000-0001-6248-3755
× Miyata, Hikaru
× Seo, Jieun
ORCID
0000-0002-0490-6059
× Nanmo, Ayaka
× Fukuda, Junji
ORCID
0000-0002-7194-8099
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | In vitro models of human hair follicle-like tissue could be fundamental tools to better understand hair follicle morphogenesis and hair drug screening. During prenatal development and postnatal cyclic hair regeneration, hair follicle morphogenesis is triggered by reciprocal interactions and the organization of the epithelial and mesenchymal cell populations. Given this mechanism, we developed an approach to induce hair peg-like sprouting in organoid cultures composed of epithelial and mesenchymal cells. Human fetal/adult epithelial and mesenchymal cells were cultured in a medium supplemented with a low concentration of either Matrigel or collagen I. These extracellular matrices significantly enhanced the self-organization capabilities of the epithelial and mesenchymal cells, resulting in spherical aggregation and subsequent hair peg-like sprouting. The length of the hair peg sprouting and associated gene expression significantly increased in the presence of a well-known hair drug, minoxidil. This approach may be beneficial for testing hair growth-promoting drug candidates. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 13, 号 1, ページ数 10, 発行日 2023-03-24 |
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| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-023-31842-y | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||
| 権利情報 | Creative Commons Attribution 4.0 International | |||||||||||||||
| 言語 | en | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Nature Portfolio | |||||||||||||||
