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Effects of oxytocin on the hair growth ability of dermal papilla cells
http://hdl.handle.net/10131/0002001263
http://hdl.handle.net/10131/0002001263bc52283b-a7a3-4159-b3c1-775ec87f02ac
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
s41598-023-40521-x.pdf (1.4 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2024-09-25 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Effects of oxytocin on the hair growth ability of dermal papilla cells | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
Kageyama, Tatsuto
× Kageyama, Tatsuto
ORCID
0000-0001-6248-3755
× Seo, Jieun
ORCID
0000-0003-1319-832X
× Yan, Lei
× Fukuda, Junji
ORCID
0000-0002-7194-8099
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Oxytocin (OXT) is a neuropeptide hormone termed "love hormone" produced and released during childbirth and lactation. It is also produced in response to skin stimulation (e.g., during hugging and massaging) and music therapy. The effects of OXT on various organs have been revealed in recent years; however, the relationship between hair follicles and OXT remains unclear. In this study, we examined the effects of OXT on dermal papilla (DP) cells that control hair growth by secreting growth/regression signals. Gene expression analysis revealed that DP signature markers were significantly upregulated in DP cells treated with OXT. In addition, we tested the hair growth-promoting effects of OXT using in vitro hair follicle organoids. OXT promoted the growth of hair peg-like sprouting by upregulating the expression of growth-promoting factors, including genes encoding vascular endothelial growth factor A (VEGFA). This study highlights the positive effects of OXT in hair follicles and may assist in the development of new treatments for alopecia. | |||||||||||||
| 言語 | en | |||||||||||||
| 書誌情報 |
en : Scientific Reports 巻 13, 号 1, ページ数 8, 発行日 2023-10-20 |
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| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-023-40521-x | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||||||
| 権利情報 | Creative Commons Attribution 4.0 International | |||||||||||||
| 言語 | en | |||||||||||||
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| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Nature Portfolio | |||||||||||||
