WEKO3
アイテム
{"_buckets": {"deposit": "fa2567f9-0783-45ef-904e-ddab23abe221"}, "_deposit": {"created_by": 3, "id": "9364", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "9364"}, "status": "published"}, "_oai": {"id": "oai:ynu.repo.nii.ac.jp:00009364", "sets": ["496"]}, "author_link": ["34660", "34661", "34665", "34662", "34664", "34663"], "item_2_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-05-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "6352", "bibliographicPageStart": "6348", "bibliographicVolumeNumber": "90", "bibliographic_titles": [{"bibliographic_title": "Analytical Chemistry"}]}]}, "item_2_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A fingerprint-based sensing approach was used to characterize in vitro cellular senescence. Secretion profiles of cultured human fibroblasts in different senescent stages were transformed into colorimetric enzyme-activity fingerprints by applying cell culture media to a polyion complex array. Analysis of the obtained fingerprints using pattern recognition methods, such as linear discriminant analysis and hierarchical clustering analysis, revealed that the polyion complex array allows the noninvasive tracking of the replicative senescence progress even in those stages where a conventional marker such as senescence-associated β-galactosidase is negative. This fingerprint-based approach should thus offer an effective way for the routine monitoring or screening of in vitro cell senescence studies.", "subitem_description_type": "Abstract"}]}, "item_2_publisher_35": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Chemical Society"}]}, "item_2_relation_13": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1021/acs.analchem.8b00795", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_14": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2018 American Chemical Society"}]}, "item_2_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00524878", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00032700", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_4": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology and DAILAB"}, {"subitem_text_value": "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo"}, {"subitem_text_value": "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo"}, {"subitem_text_value": "Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science"}, {"subitem_text_value": "Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science"}, {"subitem_text_value": "Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, JST, PRESTO, The University of Tokyo"}]}, "item_2_version_type_18": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tomita, Shunsuke"}], "nameIdentifiers": [{"nameIdentifier": "34660", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nomoto, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "34661", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshitomi, Toru"}], "nameIdentifiers": [{"nameIdentifier": "34662", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iijima, Kazutoshi"}], "nameIdentifiers": [{"nameIdentifier": "34663", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashizume, Mineo"}], "nameIdentifiers": [{"nameIdentifier": "34664", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshimoto, Keitaro"}], "nameIdentifiers": [{"nameIdentifier": "34665", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-05-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Revised maintext_v1.3_no history.pdf", "filesize": [{"value": "416.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 416300.0, "url": {"label": "Revised maintext_v1.3_no history", "url": "https://ynu.repo.nii.ac.jp/record/9364/files/Revised maintext_v1.3_no history.pdf"}, "version_id": "1a552de1-c192-4852-9f50-68bf058a4188"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Noninvasive Fingerprinting-Based Tracking of Replicative Cellular Senescence Using a Colorimetric Polyion Complex Array", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Noninvasive Fingerprinting-Based Tracking of Replicative Cellular Senescence Using a Colorimetric Polyion Complex Array"}]}, "item_type_id": "2", "owner": "3", "path": ["496"], "permalink_uri": "http://hdl.handle.net/10131/00012034", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-10-19"}, "publish_date": "2018-10-19", "publish_status": "0", "recid": "9364", "relation": {}, "relation_version_is_last": true, "title": ["Noninvasive Fingerprinting-Based Tracking of Replicative Cellular Senescence Using a Colorimetric Polyion Complex Array"], "weko_shared_id": 3}
Noninvasive Fingerprinting-Based Tracking of Replicative Cellular Senescence Using a Colorimetric Polyion Complex Array
http://hdl.handle.net/10131/00012034
http://hdl.handle.net/10131/000120348023b499-fedb-4503-9a17-6bf7593a8b95
名前 / ファイル | ライセンス | アクション |
---|---|---|
Revised maintext_v1.3_no history (416.3 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-10-19 | |||||
タイトル | ||||||
タイトル | Noninvasive Fingerprinting-Based Tracking of Replicative Cellular Senescence Using a Colorimetric Polyion Complex Array | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tomita, Shunsuke
× Tomita, Shunsuke× Nomoto, Hiroki× Yoshitomi, Toru× Iijima, Kazutoshi× Hashizume, Mineo× Yoshimoto, Keitaro |
|||||
著者所属 | ||||||
Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology and DAILAB | ||||||
著者所属 | ||||||
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo | ||||||
著者所属 | ||||||
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo | ||||||
著者所属 | ||||||
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science | ||||||
著者所属 | ||||||
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science | ||||||
著者所属 | ||||||
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, JST, PRESTO, The University of Tokyo | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A fingerprint-based sensing approach was used to characterize in vitro cellular senescence. Secretion profiles of cultured human fibroblasts in different senescent stages were transformed into colorimetric enzyme-activity fingerprints by applying cell culture media to a polyion complex array. Analysis of the obtained fingerprints using pattern recognition methods, such as linear discriminant analysis and hierarchical clustering analysis, revealed that the polyion complex array allows the noninvasive tracking of the replicative senescence progress even in those stages where a conventional marker such as senescence-associated β-galactosidase is negative. This fingerprint-based approach should thus offer an effective way for the routine monitoring or screening of in vitro cell senescence studies. | |||||
書誌情報 |
Analytical Chemistry 巻 90, 号 11, p. 6348-6352, 発行日 2018-05-07 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00032700 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00524878 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1021/acs.analchem.8b00795 | |||||
権利 | ||||||
権利情報 | © 2018 American Chemical Society | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | American Chemical Society |